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Metastasis grant recipient publishes work

  • January 25 2017

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    Metastasis grant recipient publishes work

    Dr. Marie Pendergast, Duke University School of Medicine, has published an article entitled "Inactivation of ABL kinases suppresses non–small cell lung cancer metastasis." Dr. Pendergast and fellow researcher Dr. Mark Onaitis were awarded a three-year Free to Breathe metastasis grant for this work in 2015.

    The article concludes:

    “Our data showing profound suppression of NSCLC metastasis by the ABL allosteric inhibitors in mice suggest that these compounds might be effective to treat metastatic NSCLC with a hyperactive ABL signature.”

    Allosteric ABL inhibitors are currently in clinical trials for the treatment of BCR-ABL–positive leukemia, and these drugs might be an effective strategy for overcoming resistance and inhibiting metastasis in lung cancer.

    Read more about the Free to Breathe metastasis grant at this link.

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